Neuro-Proteins Neuroscience
is one of the leading areas of scientific investigation currently at
the forefront of modern biomedical research. BRIs research programs in
neuroscience relate to the unraveling of the complex processes involved
in the pathologies of neurodegenerative diseases. By understanding the
mechanisms involved in the progression of these diseases, we aim to
identify novel molecular targets associated with defective and impaired
neurotransmission and, to develop therapeutics and diagnostics for the
treatment of neurological diseases. Protein Engineering and Design BRI
scientists use high-resolution multidimensional nuclear magnetic
resonance (NMR) and genetic engineering approaches to elucidate the
structure and function of biological macro-molecules and the structural
basis of their interactions with lead compounds. Such information is
instrumental to target selection and lead identification and can be
further utilized in the design of potential lead compounds. Plant Biotechnology BRIs
research program in plant biotechnology aims to apply genetic
engineering techniques for crop improvement benefiting the agricultural
economy of the region. BRI Traditional Chinese Medicine (TCM) Center Bioassay and Drug Development Group Since
TCM has demonstrated its effectiveness in the treatment of ailments and
diseases over its long history of empirical use, they are very likely
to possess natural products of potential therapeutic value. BRI is
utilizing this wealth of empirical experience and the vast variety of
TCMs to conduct a knowledge-based drug discovery effort. Biological
assays are being utilized to screen TCM products and botanicals for
therapeutically active compounds. Safety and Standardization Group The
standardization of TCM products and botanicals has been a challenging
issue for both scientists and regulatory bodies. In addition to the
state-of-the-art analytical testing facilities at HKUST, BRI is
developing novel methods for TCM standardization to enhance the
acceptance and commercial profitability of TCM. A library of regulatory
documents and literature as well as a database of scientific
information on traditional medicinal ingredients are also available. Reformulation and Pharmaceutics Group Reformulation
of TCM products can improve their taste, smell, and appearance.
Improved stability and method of delivery can also be achieved with new
formulations. | 
