LithuaniaVilnius Institute of Biotechnology
Centre of Excellence Institute of Biotechnology, V.A. Graiciuno 8, LT-02241 Vilnius, Lithuania. Phone: (370 5) 2602103 Fax: (370 5) 2602116 E-mail: office@ibt.lt | Founded
in 1975 as the all Union Research Institute of Applied Enzimology,
currently, the Institute of Biotechnology is mainly involved in
research and training in the fields of biotechnology and molecular
biology, including research and development of recombinant biomedical
proteins, genetic and molecular studies of restriction modification
phenomenon, developing of viruses diagnostics, epigenetic study of
small RNA, drug design and synthesis, bioinformatics. | 1: Laboratory of Biological DNA ModificationHead of LaboratoryProf. Saulius Klimašauskas, Ph.D., Dr.Habil.phone: 370 5 260214
fax: 370 5 2602116
e-mail: klimasau@ibt.lt Main topics: 1:Kinetic and molecular mechanism of DNA methylation2:Targeted covalent labeling of biopolymers 3:Novel approaches to epigenome profiling4:Functional analysis of the miRNA methyltransferase HEN1 5: Laboratory of Eukaryote Gene EngineeringHead of laboratory: Prof. Kęstutis Sasnauskas
Dr. Gintautas Žvirblis (since 2008) Main topics: 1:Hamster polyomavirus-derived virus-like particles 2:Expression of glycoproteins of mump and measles viruses in yeast 3:Technology development of long-acting recombinant proteins 4:Hantavirus vaccine and diagnostic tools 5:Biotechnological approaches to improve plant cold tolerance6:Detection and elimination of viroids and phytoplasmas 3: Laboratory of Immunology and Cell BiologyHead of the Laboratory Dr. Aurelija Zvirbliene Tel. +370 5 2602117 Fax. +370 5 2602116 E-mail: azvirb@ibt.lt Main topics:
The
Laboratory of Immunology and Cell Biology consists of three research
groups. main research topics are: antigenicity studies of recombinant
viral proteins and development of monoclonal antibodies (Dr.
A.Žvirblienė), regulation of gene expression by alternative splicing
(Dr. A.Kanopka), molecular epidemiology of tuberculosis (Dr.
P.Stakėnas).
4: Laboratory of BioinformaticsHead of the Laboratory | | Dr. Česlovas Venclovas | | Tel.: 8-5-269-1881 | | Fax.: 8-5-260-2116 | | E-mail: venclovas@ibt.lt |
Main topics:
In Bioinformatics Laboratory we mainly deal with protein sequences and
their three-dimensional structures. There are two main directions of
our research: Methods development. We
aim at improving computational methods for sequence comparison and
protein structure prediction (mainly in comparative modeling) as well
as methods for assessment of protein structure quality. Application of computational methods to biological problems. Most
often we use computational methods to characterize structure and
interactions of both individual proteins and their complexes. In these
studies we tend to focus on proteins/protein complexes that function in
DNA metabolism including DNA replication,  recombination
and repair. Our objective is to make inferences regarding structural
and functional features, molecular mechanisms, interactions, etc. that
can be tested experimentally. Most of such studies are joint
collaborations with experimentalists.
5: Laboratory of Biothermodynamics and Drug DesignHead of Laboratory: Dr. Daumantas Matulis Phone. +370 5 2691884 Fax. +370 5 2602116 Email. matulis@ibt.it Main topics: The
main research interests are in the area of anticancer drug design by
structural biothermodynamics. Several protein targets, such as the
family of human carbonic anhydrases and the family of human chaperone
proteins (especially Hsp90) were chosen as the primary targets of
interest by the laboratory. Novel small-molecule compounds are designed
in silico, synthesized by chemists, and their inhibition efficiency
measured by biophysical techniques. |
